Zeiss
LSM 880 Confocal
Plate 01ZEISS LSM 880 with Airyscan: Revolutionize Your Confocal Imaging
ZEISS MicroscopyWatch on YouTubePlate 02Training: Carl Zeiss LSM 880 Confocal Microscope
OiVM - Optical Imaging & Vital MicroscopyWatch on YouTubePlate 03Zeiss LSM880 Airyscan confocal - startup and shutdown
Cardiff University Bioimaging Research HubWatch on YouTubePlate 04Airyscan Imaging: Operating Inverted Zeiss LSM 880 Microscope using Zen Black 2.3 SP1 app.
UNTHSC MicroscopyWatch on YouTubePlate 05ZEISS LSM 880 with Airyscan: Beam Path and Principle of Airyscanning
ZEISS MicroscopyWatch on YouTube
What it is
The LSM 880 incorporates a scan head with multiple detector types. Standard configurations include a thirty-two-channel GaAsP spectral photomultiplier tube array, additional standard PMTs, a transmitted-light PMT, and an optional Airyscan module with its own GaAsP detector array for super-resolution imaging.[3]
How it works
The LSM 880 can acquire images in multiple modes including single-plane XY scans, XZ and XYZ stacks, time series (XYZT), lambda (spectral) scans, line scans, and spot scans. A tile scan function enables the collection of multiple adjacent images across a large field of view, which are then stitched into a mosaic.[3][4]
The system includes a transmitted-light detector for differential interference contrast imaging. An environmental incubation chamber with temperature regulation is available for live-cell imaging, and some configurations also support carbon dioxide control.[4][2]
What do the numbers mean?
Optics & imaging15
- Basic Optics UV/NLO[1]
- 405 CW Laser Kit for LSM 710/780[1]
- Laser Diode 405 nm[1]
- 594 Laser Kit for LSM710 with 561nm[1]
- Laser Line HeNe 594[1]
- Transmitted Lithg Detector T-PMT[1]
- Laser lines
- 405 nm, 458 nm, 488 nm, 514 nm, 561 nm, 594 nm, 633 nm; tunable 2P laser 720-1020 nm[3]
- Laser lines
- 405 nm diode; 458 nm, 488 nm, 514 nm Argon multiline; 561 nm HeNe; 633 nm HeNe[4]
- Detectors
- 32 channel GaAsP-PMT area detector, two PMTs, and a transmitted light PMT for DIC imaging[2]
- Objectives
- EC Plan-Neofluar 10x/0.30 NA WD=5.2 mm; LD LCI PA 25x/0.8 NA DIC WD=0.57 mm; LD C-Apochromat 40x/1.1 NA W Corr; Plan Apochromat 40x/1.3 NA oil; Plan Apochromat 63x/1.4 NA oil; alpha Plan-Apochromat 63x/1.46 NA oil; Plan Apochromat 40x/1.2 NA Water (FCS)[4]
- Microscope mode
- Axio Observer motorised inverted laser scanning microscope with 6 visible laser lines[4]
Control & software4
Configuration & options12
- 2+1 CH NLO Ar, 561, 633[1]
- Spectral detection 3 ch with one GaAsP[1]
- Main Beam Splitter Wheel VIS2 RGB0[1]
- Axio Observer A1 mot Basic Stand[1]
- Scanning Stage 130x100 STEP[1]
- Joystick XY; CAN[1]
- Eyepiece PL 10x/23 Br foc[1]
- DIC Slider EC PN 10x 20x/PA 20x[1]
- DIC Slider PA 63x/1.4 III HR[1]
- Stage attachment Z PIEZO WSB 500[1]
- Inverted[2]
Where are the manuals?
Generated from public-source data on file. Enter your email to access — nothing is published; details are routed privately.
Not publicly documented
Field notes
No research found yet — worked with this tool? Share what you know.
Frequently asked questions
What laser wavelengths are available on the Zeiss LSM 880?
The system can be equipped with laser lines at 405 nm (diode), 458, 488, and 514 nm (argon multiline), 561 nm (DPSS or HeNe), 594 nm (HeNe), and 633 nm (HeNe). Some configurations include a tunable multiphoton laser covering 720-1020 nm.[3][4]
What detector types are used in the LSM 880?
The instrument uses a 32-channel GaAsP spectral PMT array, additional standard PMTs, a transmitted-light PMT, and an optional Airyscan detector with a GaAsP detector array. Some configurations include two GaAsP NDD detectors as part of a BiG.2 module.[3][2]
What resolution can be achieved with the Airyscan module?
With the Airyscan detector, the system provides sub-diffraction limited imaging down to 140 nm in the XY plane and 400 nm in the Z axis.[2]
Not publicly documented
The following facts about the LSM 880 Confocal are absent from this record as of this revision. First-hand knowledge or a citation closes a gap; every submission is reviewed before publication.
No publicly documented production dates or lifecycle milestones (introduction, end of production, EOL) for the LSM 880 Confocal are on record.
Answerable by: OEM historical records or a trade-press announcement
No publicly documented variants, configuration options, or revision breakpoints of the LSM 880 Confocal are on record.
Answerable by: an OEM product catalog or an engineer who ordered or specified the tool
The control-system platform and OS era of the LSM 880 Confocal are not on record.
Answerable by: an engineer who operated it or OEM installation records
No publicly documented failure modes or field errata for the LSM 880 Confocal are on record.
Answerable by: a field service engineer, process engineer, or maintenance technician
The process node or technology generation of the LSM 880 Confocal is not on record.
Answerable by: an OEM datasheet or a fab qualification report
No research found yet — worked with this tool? Share what you know.
Sources & citations
Sources (4)Every fact above is drawn from these public sources
- [1]Inventory photo
- [2]igb.illinois.edu — igb.illinois.eduigb.illinois.edu
- [3]bioimaging.caltech.edu — bioimaging.caltech.edubioimaging.caltech.edu
- [4]imm.ox.ac.uk — imm.ox.ac.ukimm.ox.ac.uk
Last updated Aug 20, 2026.
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